Plasma cell tumor of the skull:a case report
WAN Hao-jie
HAN Feng
YANG Hua
YANG Ming
LUO Deng-jian
HUANG Rui
CHEN Wei
Abstract：Plasmacytoma,also known as myeloma,is derived from plasma cells in the bone marrow.Skull plasma cell tumors account for only a small part of extramedullary plasma cell tumors,which is a rare disease in clinic.This paper reported a case of skull plasma cell tumor,a 62-year-old female,who was admitted to hospital due to head mass accompanied by pain and discomfort for more than 6 months.The size of the frontal scalp mass was about 1.0 cm×2.0 cm,with tough texture,unclear boundary,and slight tenderness.The CT found multiple bone destruction of the skull and frontal soft tissue nodules.The plain scan+contrast-enhanceed MR images found multiple bone destruction areas of the skull and local soft tissue nodules.Eosinophilic granuloma was considered before operation.After completing preoperative preparation,skull lesion resection+cranioplasty was performed,and the total resection of the frontal lesions was confirmed by postoperative pathological examination as plasma cell tumor.After the regular treatment of daratumumab targeted therapy+ixazomib chemotherapy,no tumor recurrence was found in the reexamination of plain scan MR images 16 months after the operation.A telephone follow-up at 31 months postoperatively showed that the patient had occasional pain in the right lower limb and could walk with a crutch.In summary,skull plasma cell tumors are extremely rare,imaging examination can provide localization diagnosis for surgical treatment,but pathological examination is still the gold standard for diagnosis,postoperative radiotherapy and chemotherapy combined with pathological examination results can improve the prognosis of patients.
Keywords：Skull neoplasmsPlasma cell tumorPlasmacytomaMyelomaMicrosurgeryEfficacy
Publication Date：2024-02-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 123-125 )