Research progress on the mechanism of vasculogenic mimicry formation in glioblastoma
XIN Heng
FAN You-wu
Abstract：Vasculogenic mimicry(VM)is a vascular-like structure that exists in vascular-dependent solid tumors.It is formed by highly invasive tumor cells through self-deformation and extracellular matrix remodelingand is a special blood supply source involved in the progression of highly invasive tumors.There are two types of VM:tubular and matrix.The tubular form is made of tumor cells,not endothelial cells.The matrix form is made of extracellular matrix rather than cells.VM exists in many kinds of human malignant tumors,including glioblastoma(GBM),and is closely related to tumor proliferation,invasion and recurrence.This article reviews the concept of VM,the relationship between VM and GBM,the formation mechanism of VM in GBM and the prospect of VM therapy for GBM.
Keywords：GlioblastomaVasculogenic mimicryFormation mechanism
Publication Date：2024-02-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 119-122 )