One case of primary intracranial dysgerminoma with secondary amenorrhea
LIU Zong-wei
MU De-yong
LI Yun-song
CHU Liang-zhao
Abstract：Primary intracranial dysgerminoma(PID)is a rare tumor,mainly occurring in adolescents,which is usually found in the pineal region and sella region.The clinical manifestations of PID are mainly related to their location and size.Most PIDs are very sensitive to radiation and chemotherapy,and early treatment is essential to reduce morbidity and mortality.Due to the low incidence of this disease,there is no unified standard for the diagnosis and treatment of PID.In this paper,we reported a 20-year old female patient with PID who was admitted to our hospital because of secondary menstrual cessation for 9 months.After admission,neuroendoscopic resection was performed.The patient was confirmed as PID by postoperative pathological examination.The patient was treated with"whole brain + whole spinal cord"general radiotherapy starting from the 6th week after surgery,DT 30Gy×15 times(5 times/week);followed by a"whole brain dose"of ordinary radiation therapy,DT 24 Gy x 12 times(5 times/week).The patient was admitted to hospital and diagnosed with hypopituitarism.After diagnosis,she was treated with prednisone acetate and levothyroxine sodium replacement regularly.Three months after the completion of radiotherapy,MRI showed no obvious nodules or masses in the sella area,but her menstruation did not recovered.This suggests that early correct diagnosis and treatment of patients with PID is very important for the treatment of hormone disorders in the later period.
Keywords：Primary intracranial dysgerminomaSecondary amenorrheaRadiotherapyHypopituitarism
Publication Date：2024-01-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 60-62 )