Relationship between serum ET-1 level and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
LI Li-rong
WANG Jing-chun
ZHANG Fu-long
HAO Xu-dong
REN Shao-hua
Abstract：Objective To investigate the predictive value of serum endothelin-1(ET-1)level in delayed cerebral ischemia(DCI)after aneurysmal subarachnoid hemorrhage(aSAH).Methods The clinical data of 104 patients with aSAH who were admitted to our hospital from September 2019 to January 2023 were retrospectively analyzed.DCI was defined as the presence of low CT density or corresponding MRI findings on days 3 to 14 after the exclusion of surgery-related cerebral ischemia.The serum ET-1 level was detected by ELISA.Results Of 104 patients,39 patient(37.50%)had DCI.Multivariate logistic regression analysis showed that increased serum ET-1 level was an independent risk factor for DCI(OR=9.784;95%CI 3.458-27.688;P<0.001).ROC curve analysis showed that the area under the curve of serum ET-1 level to predict DCI was 0.840(95%CI 0.764～0.917),the cutoff value was 33.25 pg/ml,and the sensitivity and specificity were 79.5%and 76.9%,respectively.Conclusions Serum ET-1 level increases after aSAH,monitoring the change of serum ET-1 level can predict the risk of DCI.
Keywords：Aneurysmal subarachnoid hemorrhageSerumEndothelin-1Delayed cerebral ischemiaRisk factors
Publication Date：2023-10-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 643-645,648 )