Relationship between postoperative anticoagulant treatment and postoperative intracranial hemorrhage and thromboembolic events in patients with meningiomas
ZHAN Yan
YANG Yuan
MA Yan-ju
MA Jun
Abstract：Objective To investigate the relationship between postoperative anticoagulant therapy(AC)and postoperative intracranial hemorrhage(ICH)and thromboembolic events(TE)in patients with meningionmas.Methods The clinical data of 271 patients with meningiomas underwent microsurgery from January 2016 to December 2022 were retrospectively analyzed.The primary end points were postoperative ICH and TE(including mesenteric embolism,pulmonary embolism,deep vein thrombosis,cerebral infarction,myocardial infarction).The secondary endpoint was death at 30 days after surgery,and the clinical outcome was assessed using the modified Rankin Scale(mRS)score.Results Eleven patients(4.05%;7 pulmonary embolism and 4 deep vein thrombosis)suffered from TE,and the median time of occurrence was 11.17(IQR:3.71～16.79)days.ICH occurred in 16 patients(5.90%);the median time was 18.50(IQR:4～64)h after surgery;13 patients occurred within 24 h after surgery and 3 were found bleeding by CT scan after AC therapy.Multivariate logistic regression analysis showed that delayed AC therapy was an independent risk factor for ICH and TE(P<0.05).Of 11 patients with TE,8 patients(72.73%)had a mRS score of 3～6.Of 16 patients with ICH,7 patients(43.75%)had a mRS score of 3～6.Four patients died,of whom 2 died of pulmonary embolism,1 died of ICH and septic shock after abandoning treatment,and 1 died of cerebral infarction of unknown cause.Conclusions Delayed AC therapy may increase the risk of ICH and TE in patients with meningiomas after operation.TE has a greater impact than ICH on prognosis of patients with meningiomas,so it is recommended to start preventive AC therapy early after surgery.
Keywords：MeningiomasMicrosurgeryAnticoagulatant thearpyPostoperative intracranial hemorrhageThromboembolic events
Publication Date：2023-10-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 628-631 )