Relationship between serum miR-193b-3p on admition and poor prognosis of patients with aneurysmal subarachnoid hemorrhage

REN Jiang-yan; WANG Xin-xing; WANG Xiang-yang; TONG Hai-bo; REN Xiao-jia

doi:10.13798/j.issn.1009-153X.2023.09.007

Abstract：Objective To investigate the relationship between serum miR-193B-3P on admition and poor prognosis of patients with aneurysmal subarachnoid hemorrhage(aSAH).Methods A total of 159 patients with aSAH were prospectively collected from January 1,2019 to December 1,2021,and the serum miR-193b-3p level within 24 h after admission was detected by RT-PCR.GOS score was used to evaluate the prognosis 90 days after the onset,with a GOS score of 4～5 as good prognosis and a GOS score of 1～3 as poor prognosis.Results Of these 159 patients,153 patients had good prognosis,and 56(35.2%)poor prognosis(39 patients died).ROC curve analysis showed that the area under the curve of serum miR-193b-3p level within 24 h after admission to predict the poor prognosis of aSAH patients was 0.912(95%CI 0.870～0.954),the best cutoff value was 0.62,and the sensitivity and specificity were 75.7%and 94.6%,respectively.Serum miR-193b-3p levels within 24 h after admission were significantly negatively correlated with Hunt-Hess grade(r=-0.384,P<0.001)and Fisher grade on admission(r=-0.200,P=0.011),was significantly positive correlated with GCS score on admission(r=0.409,P<0.001).Multivariate logistic regression analysis showed that serum miR-193b-3p≥0.62 within 24 h after admission was an independent risk factor for poor prognosis of aSAH patients(OR=3.148;95%CI 1.017～5.167;P<0.001).Conclusions Our results suggest that serum miR-193b-3p within 24 h of admission,as a non-invasive biomarker,can not only be used to assess the severity of aSAH patients,but also can be used to predict the prognosis of patients with aSAH in the early stage.