Risk factors for venous thromboembolism in patients with meningiomas after microsurgery

WANG Xin-feng; ZHANG Ya-zhao; YU Hai-jia

doi:10.13798/j.issn.1009-153X.2023.09.005

Abstract：Objective To investigate the incidence and risk factors of venous thromboembolism(VTE)in patients with meningioma after surgery.Methods The clinical data of 110 patients with meningioma who underwent surgery from January 2018 to December 2022 were retrospectively analyzed.Pulmonary ventilation/perfusion imaging(V/Q-Scan)was performed within 2 weeks after surgery and pulmonary embolism(PE)was diagnosed according to the modified prospective study on the diagnosis of pulmonary embolism Ⅱ(PIOPED Ⅱ)criteria.Compression venous ultrasonography(CUS)was performed to diagnose deep venous thrombosis(DVT).When one or more of the following criteria were met,VTE was diagnosed:V/Q-Scan positive with/without clinical manifestations of VTE;V/Q-Scan negative but CTA positive;CUS positive with/without clinical manifestations of VTE.Results Of theses 110 patients,18 patients(16.4%)had VTE after surgery,including 2 with dyspnea or chest pain,4 with lower limb swelling or pain,and 12 without symptoms;17 with positive Q/V-Scan,1 with negative Q/V-Scan and positive chest CTA;2 patients with positive Q/V-Scan were diagnosed with PE,and 6 patients were diagnosed with DVT by CUS.Univariate analysis showed that age,body mass index,intraoperative blood loss,and operation time were associated with postoperative VTE(P<0.05).Multivariate logistic regression analysis showed that higher age(OR=1.186;95%CI 1.027-11.370;P=0.020)and body mass index(OR=3.300;95%CI 1.371-7.947;P=0.008)were independent risk factors for VTE in patients with meningoma after surgery.Conclusions The VTE after meningioma surgery should not be ignored.The risk factors such as age and body mass index should be considered in clinical practice to develop preventive measures to reduce the incidence of VTE.