Expression and clinical meanings of cell adhesion molecule CD99 in human medulloblastomas
ZHANG Peng
CHEN Xinwei
LIANG Liwei
YUAN Ling
REN Yong
Abstract：To investigate the expression and clinical meanings of cell adhesion molecule CD99 in human medulloblastomas (MB). Methods The levels of CD99 protein expression were determined by immunohistochemical technique in 107 MB samples and 15 peritumorous and normal cerebellum tissues samples. The relationship of CD99 expression with MB clinicopathological characteristics and prognosis in the patients with MB were analyzed statistically. Results The positive expression rate of CD99 (57.94%, 62/107) was significantly higher in MB tissues than that (0.00%, 0/15) in the normal cerebellum tissue (P<0.01). The expression of CD99 in MB tissues was not correlated with the patient's age and gender and tumorous histologic and molecular subtypes (P>0.05). Kaplan-Meier survival analysis suggested that the positive expression of CD99 in MB tissues was negatively correlated with the overall survival rate in the patients with MB (P<0.05). Conclusions High level of CD99 expression is significantly correlated with medulloblastoma progress and poor prognosis in the patients with MB, so it can be used as a novel biomarker and a new target for treating medulloblastomas and a novel index of predicting the prognosis in the patients with MB .
Keywords：MedulloblastomasCD99PrognosisExpressionImmunohischemical technique
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 547-549 )