Effect of intranasal administration of dexmedetomidine on cerebral hemodynamics during general anesthesia in elderly patients with cerebral aneurysms undergoing intervenient therapy
TAN Shigang
LU Hanjie
SONG Xiaoyang
Abstract：To investigate the effect of intranasal administration of dexmedetomidine on the cerebral hemodynamics during general anesthesia in the elderly patients with cerebral aneurysms undergoing intervenient therapy. Methods Of 60 patients with intracranial aneurysms undergoing intervenient therapy, 30 (observed group) received intranasal administration of 0.5 μg/kg dexmedetomidine and 30 (control group) intranasal administration of isovolumetric physiological saline 30 minutes before the induction of general anesthesia. The endotracheal intubation was performed when the bispectral index value was between 40 and 60 after the anesthesia induction. The mean arterial pressure (MAP), heart rate (HR), left middle cerebral artery peak blood flow velocity(Vp-MCA), left middle cerebral artery mean blood flow velocity (Vm-MCA) and pulsatility index (PI) were recorded 30 minutes after the intranasal administration of drug (T0), immediately after endotracheal intubation (T1), 1 minute after the intubation (T2), 3 minutes after the intubation (T3), and 5 minutes after the intubation (T4). Results The MAP, Vp-MCA, Vm-MCA and HR were significantly higher and PI was significantly lower at T1-3 than those at T0 in the control group (P<0.05). The MAP, Vp-MCA, Vm-MCA and HR were significantly lower, and PI was significantly higher in the observed group than those in the control group at T1~3 (P<0.05). Conclusion The intranasal administration of 0.5 μg/kg dexmedetomidine 30 minutes before the induction of general anesthesia can inhibit the cardiovascular responses and increase cerebral blood flow during the intubation in the elderly patients with cerebral aneurysms undergoing intervenient therapy.
Keywords：Cerebral aneurysmsIntervenient therapyDexmedetomidineNasal dripElderly patientsIntubation periodCerebral hemodynamics
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 537-539 )