Meta-analysis of impact of tirofiban on clinical effect of mechanical thrombectomy on acute ischemic stroke
HUANG Chang-heng
YU Yaoyu
YAO Zi-tong
Abstract：To investigate the safety of tirofiban and its effects on the patients with acute ischemic stroke udergoing mechanical thrombectomy. Methods The database CNKI, PubMed, Embase, and Cochrane were searched for the randomized controlled trials of effects of tirofiban on the patients with acute ischemic stroke undergoing mechanical thrombectomy. Meta-analysis of the vascular recanalization rate, bleeding rate and prognosis 3 months after the treatment was performed by ReVMan5.3 statistical software. Results A total of 6 studies were included and 376 patients were enrolled. Meta-analysis showed that there was insignificant effects of tirofiban on the revascularization rate, bleeding rate and prognosis 3 months after the treatment in the patients with acute ischemic stroke undergoing mechanical thrombectomy. Conclusion It is suggested that it is unnecessary for the patients with acute ischemic stroke undergoing mechanical thrombectomy to be treated by tirofiban because tirofiban does not enhanced the cerebral hemorrhage, but also it is not helpful to the improvement of the patients'prognosis.
Keywords：Acute ischemic strokeTirofibanMechanical thrombectomyMeta analysis
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 527-530 )