Effect of dezocine combined with dexmedetomidine on the analgesia and sedation after craniotomy in patients with spontaneous intracerebral hemorrhage
WU Yong
HUANG Shu-lan
GUAN Long-bin
RONG Jia-bin
Abstract：Objective To explore the effect of dezocine combined with dexmedetomidine on the analgesia and sedation after craniotomy in the patients with spontaneous intracerebral hemorrhage (SICH). Methods Of 56 patients with SICH who underwent craniotomy for evacuation of hematomas in our hospital from September, 2017 to September, 2018, 28 (observation group) were treated with dexmedetomidine and dezocine, and 28 (control group) were treated with dezocine and midazolam. The Ramsay sedation score, the score of analgesia visual analogue scale (VAS) and nausea and vomiting VAS, mean arterial pressure (MAP), heart rate (HR), blood oxygen saturation (SPO2), rebleeding rate and the length of hospital stays were compared between both the groups. Results The Ramsay sedation scores and SPO2 were significantly higher in the observation group than that in the control group 2, 6, 12 and 24 hours after the treatment (P<0.05). The scores of analgesia VAS and nausea and vomiting VAS, MAP and HR were significantly lower than those in the control group 2, 6, 12 and 24 hours after the treatment (P<0.05). MAP and HR were significantly lower in the observation group in the observation group after the treatment than those before the treatment in the observation group (P<0.05). SpO2 was significantly higher after the treatment than that before the treatment in the observation group (P<0.05). There was insignificantly difference in the rebleeding rate between both the groups (P>0.05). The hospital stays was significantly shorter in the observation group than that in the control group (P<0.05). Conclusions Dexmedetomidine combined with dezocine has significantly effect on analgesia and sedation and can stabilize postoperative hemodynamic parameters and reduce hospital stays in the patients with SICH undergoing craniotomy.
Keywords：Spontaneous intracerebral hemorrhageDexmedetomidineDezocineAnalgesiaSedation
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 480-482 )