Effects of concussion induced by blast on cognitive function and serum levels of S-100B and hs-CRP
GAO Yu-song
WANG Bing-jun
WANG Hai-wei
WEN Jin
ZHANG Xiao-na
YAN De-qi
Abstract：Objective To investigate the changes in the serum levels of hypersensitive C-reactive protein (hs-CRP ) and S-100B as well as cognitive function in the patients with concussion induced by blast. Methods The cognitive function was determined by Mini-mental State Examination (MMSE) and the serum levels of S-100B and hs-CRP were determined in the patients with blast-induced concussion (observed group) and 20 healthful subjects (control group). The relationship of MMSE score with the serum levels of S-100B and hs-CRP were analyzed by bivariate correlation test. Results MMSE total scores were significantly lower in the observed group than those in the control group on admission to the hospital (P<0.05). The serum levels of S-100B 3 hours after the blast injury and the serum levels of hs-CRP 5 hours after the blast injury were significantly higher in the observed group than those on admission to the hospital in the control group (P<0.05). There were insignificant differences in MMSE total scores and the serum levels of S-100B and hs-CRP 2 weeks after the blast injury between both the groups (P>0.05). The cognitive function level determined by MMSE was negatively related to the serum levels of S-100B and hs-CRP in the patients with blast-induced concussion (P<0.05). Conclusions The elevated serum S-100B and hs-CRP levels can be used as acute serological indicators for evaluating cognitive function disturbance in the patients with concussion induced by blast. It is suggested that the cognitive function disturbance can be reversed by proper treatment.
Keywords：Blast-induced concussionHypersensitive C-reactive proteinS-100BConcussioncognitive function
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 470-472 )