Acute study of biocompatibility of carbon fiber composite artificial skull plate
ZHANG Mengjie
ZHOU Chunpeng
CHEN Huahui
ZHANG Gangli
Abstract：Objective To evaluate the biocompatibility of carbon fiber composite artificial skull plate(CFCASP) in acute phase. Methods The biocompatibility of CFCASP was observed by cytotoxicity test, acute toxicity test in mice, acute hemolysis-test in rabbits and sensitization test in guinea pigs. Results①The relative proliferation rates of L929 cells cultured in the media containing the extracts from carbon fiber composite material, recombinant human bone morphogenetic protein-2 containing carbon fiber composite material and titanium net for 24~72 hours were over 75% and, there was insignificant difference in the relative proliferation rates among the three groups (P>0.05) and the cytotoxicity was grade I, which indicated no obvious cytotoxicity. ② The activities were well and no adverse reactions and obvious acute toxicity were observed in the mice 4, 24, 48 and 72 hours after intraperitoneal injection of the extracts of the above-mentioned three materials and physiological saline. ③The acute hemolysis test showed that the hemolysis rates of the extracts from the above-mentioned materials all were less than 5% in the New Zealand white rabbits, and there was insignificant difference in the hemolysis rate among the three materials (P>0.05). ④No any sensitive reactions were observed in the guinea pigs receiving intracutaneous injection of the extracts from the above-mentioned materials. Conclusions CTCASP has good biocompatibility and meets the clinical application standards of domestic medical materials.
Keywords：BiocompatibilityCarbon fiber composite materialArtificial skull plate
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 356-360 )