Composition of pathogenic bacteria of nosocomial intracranial infection and analysis of their resistance to drugs
DONG Feng
ZHENG Zhixing
CHEN Xin
GUO Dawen
ZHAO Shiguang
Abstract：Objective To analyze the distribution of pathogenic bacteria of nosocomial intracranial infection and their resistance to drugs in order to provide the basis for clinical choice of the appropriate antibiotics. Methods The data of 877 strains of intracranial infection pathogenic bacteria who were positive on the cerebrospinal fluid culture and their resistance to drugs from January, 2016 to April, 2018 were investigated retrospectively. Results Of these 877 strains of the bacteria, 716 (81.46%) including methicillin-resistant coagulase-negative staphylococci (46.86%), methicillin-sensitive coagulase-negative staphylococci (18.70%) and so on, were Gram-positive bacteria and 161 (18.36%) including Acinetobacter Bauman, Klebsiella pneumonia and so on, were Gram-negative. The Gram-positive bacteria were sensitive to tigecycline, vancomycin and linezolid. Acinetobacter Bauman had widespread drug resistance;Klebsiella pneumoniae was sensitive to carbapenem and enzyme inhibitors. Conclusion Understanding of distribution and drug resistance of pathogenic bacteria is very helpful to the clinical rational selection of antibiotics in early stage of intracranial infection, improving the prognosis of patients, and decrease in the production of drug-resistant strains.
Keywords：Intracranial infectionPathogenic bacteriaDrug resistance
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 333-335 )