Meta analysis of curative effect of tandospirone on epileptic patients with depression and anxiety
ZHANG Wei
LIU Yong
WANG Wei-wen
JIN Jun-gong
MENG Qiang
Abstract：Objective To assess the clinical efficacy and safety of tandospirone in epileptic patients with depression and anxiety． Methods Randomized controlled trials (RCTs) of treatment of epileptic patients with depression and anxiety by tandospirone were searched from the data bases including Pubmed,Cochrane,ScienceDirect,Embase,CNKI,VIP and Wanfang Database.Meta-analysis of the curative effect of tandospuirone on the epileptic patients with depression and anxiety was conducted with Revman 5.3.Results Six RCTs including 462 epileptic patients with depression and anxiety were derived from the mentioned-above data bases.The meta-analysis showed that the scores of Hamilton Anxiety Scale (SMD=-1.01,95%CI-1.91～-0.11,P=0.03) and Hamilton depression scale (SMD=-1.57,95%CI-2.42～-0.72,P=0.0003) and adverse events rate (OR=0.43,95%CI 0.22～0.82,P=0.01) were significantly lower in tandospirone group than those in control group.The effective rate was significantly higher in tandospirone group than that in control group (OR=3.31,95%CI 1.97～5.56,P＜0.00001).Conclusions The curative effect of tandospirone on the epileptic patients with depression and anxiety and its safety are good.
Keywords：TandospironeEpilepsyDepressionAnxietyCurative effectMeta analysis
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 200-203 )