Application of fluorescein sodium combined with fluorescence microscope to resection of intracranial malignant tumors

SUN Lian-jie; DONG Jun; GAO Feng; LI Ke; ZHANG Zhen-yu; ZHANG Cheng; MAITIYIMING Tohti; YANG Xiao-peng

Abstract：Objective To explore the technique of low dose fluorescein sodium (FLS) combined with yellow 560 nm fluorescence microscope-assisted neurosurgery for intracranial malignant tumors.Methods Fifty-one patients with intracranial malignant tumors diagnosed before the surgery were treated by low dose FLS combined with yellow 56 nm fluorescence microscope-assisted neurosurgery in the Department of Neurosurgery of Xinjiang Uygur Autonomous Region People's Hospital from September 2016,to February,2018.Of 51 patients,33 had glioblastomas,6 anaplastic astrocytmas,4 metastatic tumors,3 anaplastic oligodendrocytomas,3 glial sarcomas and 2 medulloblastoma.Results The fluorescence developed and the visualization of tumorous boundary was improved during the operation in all the patients.There were no allergic or other adverse reactions in all the patients.Of 51 patients,32 received the total resection of the tumors,13 subtotal and 6 partial.The median Karnofsky performance scale (KPS) score was 80.0 point in these 51 patients after the operation.The KPS score was improved in 16 patients,decreased in 15 and unchanged in 20 after the operation.Conclusion The application of low dose FLS to the neurosurgery is safe and helpful to identification of the tumorous boundary and increase in the extent of tumor resection in the patients with intracranial malignant tumors.