Study of visual conduction pathway by DTI in 24 children with sellar tumors
LUO Bin
MIAO Su-hua
HE Le
ZHAO Ya-peng
XU Cheng-wei
ZHU Jin
ZHANG Qing-hui
ZHANG Yu-qi
Abstract：Objective To assess visual impairment by MR diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) in children with sellar tumors. Methods DTI and DTT imaging were performed, and the fractional anisotropy (FA) values of the bilateral optic nerves were calculated and statistically analyzed in 24 children with sellar tumors (including 12 optic chiasm gliomas, 7 sellar craniopharyngiomas, 2 teratomas in the third ventricles, 2 hypothalamic hamartomas, and 1 clivus chordoma. Results The optic chiasms were destroyed by the tumors in 12 children with sellar tumors and were compressed by the tumors in 12 children with sellar tumors according to the locations and shapes of the optic chiasms and their spatial relationships with the tumors. The FA values of the bilateral optic nerves were significantly lower in 12 children with destroyed optic chiasms than those in 12 children with the compressed optic chiasms (P<0.05). Conclusions DTI and DTT imaging examination can clearly show the spatial relationship between sellar tumors and visual nerve fiber bundles in children with sellar tumors. The obtained FA values can be used to evaluate the nature and degree of damage to the optic nerve and visual pathway by the tumors.
Keywords：ChildrenSellar tumorsMR diffusion tensor imagingOptic chiasm injury
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 129-131 )