Effect of erythropoietin combined with hypothermic treatment on neonates with hypoxic-ischemic encephalopathy
LIU Fang
LIU Ying
Abstract：Objective To investigate the effect of erythropoietin (EPO) combined with hypothermic treatment on serum Tau protein levels in the neonates with hypoxic-ischemic encephalopathy (HIE). Methods Of 98 neonates with HIE treated in Department of Neonatology in our hospital from February, 2014 to April, 2017, 30 (hypothermia group) were treated alone by hypothermia, 34 (EPO group) alone by reconstruction human (rh) EPO, and 34 (combination group) by rhEPO combined with hypothermia. The serum Tau protein levels were detected and Neonatal behavioral neurological assessment (NBNA) were performed before and 2, 7, 14, and 28 days after the treatment. The relationship between the serum Tau protein level and NBNA scores was analyzed. Results The serum Tau protein levels were significantly lower and the NBNA scores were significantly higher in the combination group than those in the hypothermia and EPO groups 7, 14 and 28 days after the treatment (P<0.05). Spearman correlation analysis showed that the serum Tau protein levels were negatively correlated with NBNA scores in all the groups (P<0.05). Conclusions EPO combined with hypothermia can significantly reduce serum Tau protein levels and effectively improve neurological development in the neonates with HIE. The serum Tau protein level can be used as a clinical indicator to evaluate the neurobehavioral development outcomes in the neonates.
Keywords：Hypoxic-ischemic encephalopathyNeonatesErythropoietinHypothermiaTau proteinNeuroligical development
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 795-797 )