Clinical effect of dexmedetomidine combined with butofinol on analgesia and sedation in patients hypertensive cerebral hemorrhage
WANG Ben-lin
WANG Hui-xing
ZHOU Hai-xu
YUAN Yang
Abstract：Objective To evaluate the efficacy and safety of dexmedetomidine combined with butofinol in the patients with hypertensive cerebral hemorrhage (HCH). Methods Of 50 patients with HCH, 30 (observed group) were treated by dexmetomidine combined with butofinol and 20 (control group) was treated with iprazine hydrochloride and chlorpromazine hydrochloride. The scores of visual analogue scale (VAS) and Ramsay sedation scale, blood pressure, the incidence of nausea and vomiting were determined and compared between the two groups. Results The scores of VAS and Ramsay sedation scale, systolic and diastolic blood pressures and incidence of nausea and vomiting were significantly lower in the observed group than those in the control group 2, 6, 12 and 24 hours after the treatment (P<0.05). Conclusions Dexmedetomidine combined with butofinol can effectively reduce the restlessness and incidence of nausea and vomiting, and has good analgesic and sedative effects compared to iprazine hyarochloride and clorpromazine hyarochloride in the patients with HCH.
Keywords：Hypertensive cerebral hemorrhageDexmedetomidineButofinolAnalgesiaSedation
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 792-794 )