Curative effect of levetiracetam combined with sertraline hydrochloride on epilepsy children with depression

XING Qiong-bo; ZHAO Xiu-ying; WU Xiao-na

doi:10.13798/j.issn.1009-153X.2018.05.006

Abstract：Objective To evaluate the clinical curative effects of levetiracetam combined with sertraline hydrochloride on epilepsy children with depression.Methods The clinical data of 112 epilepsy children with depression aged 6~15 years,of whom,56 were 6~12 years old(group A)and 56 were13~15 years old(group B),were analyzed retrospectively.All the children were treated by levetiracetam combined with sertraline hydrochloride for 12 months. The frequency of seizures, Wechsler intelligence scale for children revised in China(WISC-CR),Hamilton Depression Rating Scale 17(HAMD-17),and quality of life in children with epilepsy(QOLCE),body mass index(BMI)and incidence of adverse reactions in both groups were determined and analyzed before and after the treatment.Results The scores of WISC-CR and QOLCE were significantly higher and the frequency of seizures and the scores of HAMD-17 were significantly lower in both the groups after the treatment than those before the treatment (P<0.05). The scores of WISC-CR and QOLCE were significantly higher and the frequency of seizures and the scores of HAMD-17 were significantly lower in group A than those in group B after the treatment(P<0.05).However,there were insignificant differences in the BMI and the incidence of adverse reactions between the two groups after the treatment (P>0.05). Conclusions The curative effects of levetiracetam combined with sertraline hydrochloride on epilepsy children with depression are good in all the age groups,but their effects on epilepsy children with depression aged 6~12 years are better than those on epilepsy children with depression aged 13~15 years.