Curative effects of mild hypothermia on spontaneous intracerebral hemorrhage and its safety

LIN Qing-guo; YANG Xiu; YANG Wu-shuang; LIU Dong-hui; WANG Wen-yang; MENG Han; ZHENG Jia-di; HUANG Hui-yong

doi:10.13798/j.issn.1009-153X.2018.04.006

Abstract：Objective To explore the curative effect of mild hypothermia on spontaneous intracerebral hemorrhage(SIH)and its safety. Methods Seventy-eight patients with acute SIH, who were treated in our hospital from January, 2015 to March, 2017, were divided into hypothermia group,in which 39 received routine treatment and mild hypothermia therapy and normothermia group,in which 39 recived routine treatment under the normothermia.The physiological parameters,intracranial pressure(ICP)and biomarkers in the cerebrospinal fluid(CSF)were dynamically monitored in all the patients.The curative outcomes were assessed by GOS 6 months after the treatment. Results The heart rate, serum K+concentration, blood pH, blood residual alkali concentration, CSF glial fibrillary acid protein and ubiquitin carboxy terminal hydrolase L1 levels and ICP were significantly lower in the hypothermia group than those in the normothermia group 24,48,72 and 120 hours after the treatment(P<0.05).The six-month following-up results showed that the mortality and rate of unfavorable outcome in hypothermia group was significantly lower than those in the normothermia group(P<0.05).However, the occurrence rate of complications such as pulmonary infection and hypokalemia was significantly higher in the hypothermia group than that in the normothermia group(P<0.05).Conclusions It is suggested that mild hypothermia therapy can reduce ICP and protect the injured brain tissues and improve the prognoses in the patients with SIH.Adequate attention should be paid to the monitoring of physical parameters and relevant complications.