Meta-analysis of relativity of ANP serum levels and genetic polymorphisms with ischemic stroke risk
WANG Mou-long
LI Ai-hong
QU Liang-suo
Abstract：Objective To evaluate the relativity of the serum level and genetic polymorphism of atrial natriuretic peptide(ANP) with the risk of ischemic stroke(IS).Methods The databases including PubMed,CISCOM,CINAHL,Web of Science,EBSCO,Cochrane Library,CBM,VIP and Wanfang were searched for the original articles of random-control study of the relationship of the serum levels and genetic polymorphism of ANP with the risk of IS and published before 2014. A meta-analysis was performed with Stata 12.0 software.Results Twelve original articles about clinical study of the relationship of the serum levels and genetic polymorphism of ANP with the risk of IS including 1,285 patients with IS and 1,088 healthy subjects serving as control were acquired from the above-mentioned databases.Meta-analysis showed that ANP 2238 T/C polymorphism might increase the risk of IS(C allele vs.T allele:OR=2.26,95% CI:1.59~3.23,P<0.01;TC+CC vs.TT:OR=2.26,95% CI:1.34~3.81,P=0.002;respectively)and ANP 1837 G/A and 664 G/A polymorphisms were insignificantly related to IS risk.The level of serum ANP was significantly higher in the patients with IS than that in the healthy subjects(SMD=3.12,95% CI:1.16~5.07,P=0.002).Conclusion It is suggested that the serum levels and genetic polymorphism of ANP was associated with IS.
Keywords：Atrial natriuretic peptideIschemic strokeGenetic polymorphismSerumMeta-analysis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 161-164 )