Correlativity of serum level of neuron specific enolase with pressure times time dose of intracranial pressure in patients with severe traumatic brain injury
LI Jian-jun
Abstract：Objective To investigate the changesin the serum levels of neuron specific enolase (NSE) and intracranial pressure (ICP) in patients with severe traumatic brain injury (sTBI) after craniotomy,and to analyze the correlativity of the level of NSE with pressure times time dose of ICP (PTD-ICP).Methods The postoperative ICP in 32 patients with sTBI was continuously monitored and the serum level of NSE was detected once every 12 hours and PTD-ICP were calculated once every 12 hours.The correlation between NSE and PTD-ICP was analyzed and the predictive efficacy of level of serum NSE on PTD-ICP＞0 was evaluated.The relationship between the serum level of NSE and PTD-ICP was verified in other 22 patients with sTBI (verification group).Results In retrospective group,the levels of serum NSE ranged from 20.46 to 79.74 μg/L and PTD-ICP ranged from 0 to 537.65 mmHg/5 min within the first 3 days after the operation.The area under ROC curve of the serum level of NSE to predict PTD-ICP＞0 was 0.937 and the best cut-off value of NSE was 51.93 μg/L.When the level of NSE was above 51.93 μg/L,a significantly positive correlation of the serum level of NSE with PTD-ICP was showed (P＜0.05).In verification group,the sensitivity was 0.738,the specificity was 0.955 and kappa was 0.696 (P＜ 0.05) if using NSE ≥ 51.93 μg/L to predict PTD-ICP＞0.Conclusion There is a significantly positive correlation between serum level of NSE and PTD-ICP early after the operation in the patients with sTBI.The serum level of the NSE is helpful to predicting the risk of ICP ＞ 20 mmHg in the next 12 h.
Keywords：Neuron specific enolaseSevere traumatic brain injuryIntracranial pressurePrognosis
Publication Date：2018-02-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 78-80 )