Analysis of risk factors related to prognosis in patients with spinal cord ependymoma undergoing microneurosurgery

WANG Jin-long; LIU Ya-jun; LUO Kun

Abstract：Objective To investigate the risk factors related to the prognosis in the patients with spinal cord ependymomas undergoing microneurosurgery.Methods The clinical data of 80 patients with intramedullary ependymomas,who underwent surgery in our hospital from June, 2007 to February, 2017, were analyzed retrospectively. The factors related to prognosis were statistically analyzed. The spinal function was assessed before and after the surgery by European Myelopathy Scores (EMS). All the patients were followed up for (37.6 ± 19.0) months. Results Of 80 patients with intramedullary ependynomas, 51 received the total resection of the tumors,25 subtotal and 4 parts.Univariate analysis showed that the rates of preoperative fecal and uninary incontinences occurrence and preoperative syringomyelia occurrence were significantly lower in 49 patients with good outcomes than those in 31 patients with poor outcomes (P<0.05). Multivariate logistic regression analysis showed that the risk factors related to the prognosis included the preoperative fecal and uninary incontinences and syringomyelia in the patients with intramedullary ependynomas undergoing surgery(P<0.05).EMS of the spinal function were significantly higher at the last following up than those before the operation and 3 days after the operation(P<0.01).Conclusions The prognoses after the surgery are poor in the intramedullary patients with the preoperative fecal and uninary incontinences or syringomyelia.The spinal function tends to be stable during the postoperative short period and the long-term curative effects of the surgery are good in the patients with intramedullary ependynomas.