Diagnosis and treatment of pleomorphic xanthoastrocytoma:a report of 22 cases
ZHANG Zhi-yuan
WANG Han-dong
FAN You-wu
WU Jin-rong
Abstract：Objective To investigate the diagnosis and treatment of pleomorphic xanthoastrocytoma(PXA).Methods The clinical data of 22 patients with PXA confirmed by postoperative pathological examination who underwent surgery through different approach were analyzed retrospectively. Results The main clinical symptoms included epilepsy, headache and so on. Of 22 PXA, 63.6% were located in the cerebral cortex and 66.7% cystic.Most PXA cells were pleomorphic ones with immunohistochemically positive GFAP.Of 22 patients with PXA,16 received total resection of PXA,4 subtotal and 2 part.Nineteen patients were followed up for 1 to 8 years.Ten patients had normal life,4 had self-care capacity,2 needed care for activities of daily living and 3 died during the following-up.PXA recurred in 10 patients. Conclusions Most of PXA are of the characters of benign tumors, but a small number of PXA may have malignant potential.MRI is of value for diagnosis,surgical resection and assessment of prognosis of PXA.The definite diagnosis of PXA depends on the histopathological examination.Radiotherapy and/or chemotherapy should be performed after the surgery in the patients with residual tumors or aanaplastic PXA or recurrent PXA in order to improve the patients'prognoses.
Keywords：Pleomorphic xanthoastrocytomaDiagnosisTreatmentCurative effect
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 801-803 )