Effect of progesterone on cells apoptosis of spinal cord after acute ischemia reperfusion injury in rabbits
LI Chan
LI Yun
JIN Zijuan
TAO Bo-ni
YANG Peng
Abstract：Objective To explore effect of progesterone on the cells apoptosis of spinal cord after acute ischemia reperfusion injury in rabbits. Methods Ninety rabbits were randomly divided into sham operation group (n=30), spinal cord injury (SCI) group (n=30) and progesterone treatment group (n=30). The cell apoptosis in the injured spinal cord and the movement function of posterior limbs were determined respectively by terminal deoxynucleotidayl transferase dUTP nick end labeling and Basso, Beattie & Bresnahan (BBB) locomotor rating scale 12, 24, 36, 48, 72 and 336 hours after the injury in all the animals. Results The apoptotic cells were observed in the injured spinal cord 12 hours after SCI, and the apoptosis peaked 48 hours after SCI and apoptotic cells were still observed 14 days after SCI. The number of apoptosis cells was significantly fewer in progesterone treatment group than that in SCI group 36, 48, 72 and 336 hours after SCI (P<0.05). The BBB locomotor rating scale scores were significantly higher in progesterone treatment group than those in SCI group 36, 48, 72 and 336 hours after SCI (P<0.05). Conclusion It is suggested that progesterone may play a neuroprotective effect by inhibiting apoptosis in the rabbits with acute ischemia- reperfusion injury.
Keywords：Spinal cordIschemia-reperfusion injuryProgesteroneApoptosisRabbits
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 767-770 )