Meta-analysis of effects of hyperbaric oxygen therapy on clinical outcomes in Asian patients with aneurysmal subarachnoid hemorrhage
AKU Bu-qian
LI Xiang-long
LUO Xin
ZHOU Jiang
LI Hao
LIU liang
CHEN Li-gang
XIA Xiang-guo
Abstract：Objective To evaluate the effects of hyperbaric oxygen therapy (HBOT) on clinical outcomes in the postoperative Asian patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods Systematic literature retrieval from the data bases including Ovid, PubMed, MEDLINE, EBSCD and EMBASE was carried out to obtain randomized controlled trials of HBOT in the postoperative Asian patients with aSAH before February, 2017. Methodological quality assessment and data collection were performed by two individual reviewers, and Meta-analysis was performed with software RevMan 5.3. Results A total of 10 original articles about randomized controlled trails of HBOT including 856 postoperative patients with aSAH were derived from the above-mentioned data base. The Meta-analysis results showed that there are significant differences in the good prognosis according to GOS (RR=1.19, 95%CI:1.04~1.36, P=0.010), activity of daily living scores (MD=-11.99, 95%CI:-13.95~-10.3, P=0.00001), Barthel index (MD=12.42, 95%CI: 5.82~19.03, P=0.0002), symptomatic vasospasm (RR=0.56, 95% CI: 0.41~0.78, P=0.0006), mean blood flow velocity of middle cerebral artery (MD=-10.07, 95%CI:-16.33~-3.80, P=0.002) between the HBOT group and control group. Conclusions According to the perspective of the existing clinical evidence, the prognoses may be improved by HBOT in the postoperative Asian patients with aSAH.
Keywords：Aneurysmal subarachnoid hemorrhageHyperbaric Oxygen therapyCurative effectPostoperative patientsMeta-analysis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 757-760 )