Application of DSA combined with serum SICAM-1 to the evaluation of cerebral vasospasm after SAH due to aneurysmal rupture
XIE Fei
CHEN Zhi-yuan
ZENG Jia-liang
Ye Yong-qiang
Abstract：Objective To explore the feasibility of the application of DSA combined with serum soluble intercellular adhesion molecule (SICAM-1) to the evaluation of cerebral vasospasm (CVS) severity after subarachnoid hemorrhage (SAH) caused by the aneurysmal rupture. Methods The diameters of the cerebral blood vessels including the first and second sections of the middle cerebral arteries and anterior cerebral arteries were determined by DSA in 56 patients with ruptured intracranial aneurysms undergoing emergency surgery. The severity of CVS was assessed by DSA outcomes combined with Hunt-Hess grading system. The serum levels of SICAM-1 were determined in all the patients. The relationship of the severity of CVS with the serum levels of SICAM-1 was analyzed. Results Of 26 with postoperative CVS of 56 patients with ruptured aneurysms, 9 suffered from mild CVS, 10 from moderate and 7 severe. From 1 to 10 days after the surgery, the mean serum level of SICAM-1 [ (664.64 ± 98.71) ng/ml] was significantly higher in 7 patients with severe CVS than that [ (532.79±69.71) ng/ml] in 10 with moderate CVS (P<0.01), which was significantly higher than that [ (393.47± 79.51) ng/ml] in 9 with mild CVS (P<0.01), which was significantly higher than that [ (273.47±86.54) ng/ml] in 30 without CVS (P<0.01). Conclusion The serum level of SICAM-1 was positively related to the severity of CVS in the patients with SAH due to ruptured intracranial aneurysms undergoing the surgery. It is suggested that the serum level of SICAM-1 may serve as an index of CVS severity.
Keywords：Intracranial aneurysmsSubarachnoid hemorrhageDigital subtraction angiographySoluble intercellular adhesion molecule-1Cerebral vasospasm
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 617-618,622 )