Relationship of pathological grade of diffuse glioma with the expressions of VEGF, MMP-9 and uPA in glioma tissues
WANG Jia
WANG Huan-ming
FENG Hua
LIANG Yi
DU Bo-lin
XU Hai-bo
Abstract：Objective To evaluate the relationship of pathological grade of diffuse glioma with the expressions of vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator (uPA) in the glioma tissues. Methods The expressions of MMP-9, VEGF and uPA were determined by immunohistochemical method in 20 samples of diffuse low-grade gliomas tissues (low grade group) and 25 samples of diffuse high-grade gliomas tissues (high grade group). The relationship of pathological grade of gliomas with the expressions of VEGF, MMP-9 and uPA was analyzed. Results The rates of positive expressions of VEGF and MMP-9 were significantly higher in the high grade group respectively than those in the low grade group (P<0.05), but there was insignificantly difference in the positive expression rate of uPA between both the groups (P>0.05). Conclusion It is suggested that the high expressions of VEGF, MMP-9 may play important roles in the pathogenesis and development of diffuse gliomas.
Keywords：Diffuse gliomaPathological levelVEGFMMP-9uPAExpressionRelationship
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 560-562 )