Relationship of serum level of amyloid protein A with prognoses in patients with acute spontaneous intracerebral hemorrhage
ZHU Guo-ting
CHEN Si-si
HUANG Shu-lan
Abstract：Objective To investigate the relationship between the level of serum amyloid protein A (SAA) and clinical prognoses in the patients with spontaneous intracerebral hemorrhage (sICH). Methods The levels of SAA before the operation and 1, 3, 5 and 7 days and at discharge from the hospital were determined in 78 patients with sICH receiving drilling for drainage. The relationship between the levels of SAA and prognoses 6 months after the operation was analyzed by univariate and multivariate logistic regression analyses. Results Of 78 patients, 56 had good prognoses and 22 poor according to GOS 6 months after the operation. The levels of SAA, D-Dimer, the rate of low GCS score before the operation, the rate of rebleeding after operation, and the levels of SAA 1, 3, and 5 days after operation were significantly higher in the patients with poor prognoses than those in the patients with good prognoses (P<0.05). The multivariate analysis showed the low GCS score before operation, rebleeding and high level of SAA 1 day after the operation were independent risk factors for poor outcomes (P<0.05). Conclusions It is suggested that the level of SAA 1 day after operation is very helpful to prediction of the prognoses because its high levels is an independent risk factor for the prognoses in the patients with sICH.
Keywords：Acute intracerebral hemorrhageSerum amyloid protein APrognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 539-541 )