Effects of astraglaus polysaccharide on learning and mermory and hippocampal BDNF expression in rats with traumatic brain injury
YUAN Hong-gang
HUANG Shu-lan
LIU Hua-ming
ZHANG Chun-wei
Abstract：Objective To explore effects of astraglaus polysaccharide (APS) on learning and mermory and expression of brain-derived neutrotrophic factor (BDNF) in the hippocampi of rats with traumatic brain injury(TBI).Methods Sixty rats were randomly divided into three groups of 10 animals each3,i.e.sham operation group,ASP group,in which TBI model was established and the rats were treated by oral administration of ASP for 8 weeks and control group,in which TBI model was established and the rats were treated by oral administration of 0.9％ saline solution.The learning and memory function were determined by morris water maze after the treatment and then the expression of BDNF protein and mRNA in hippocampal tissues were determined by western-blot and RT-PCR in all the rats.Results The escape latent period was significantly longer platform retention time and platform distance percentage were significantly shorter and the expression of BDNF in the hippocampal tissues was significantly lower in the control group than those in the sham operation group (P＜0.05).The escape latent period was significantly shorter and platform retention time and platform distance percentage were significantly longer and the expression of BDNF in the hippocampal tissues was significantly higher in ASP group than those in the control group (P＜0.05).Conclusion It is suggested that APS can improve learning and memory functions in the rat with TBI and its mechanism may be related to upregulation of the expression of BDNF in the hippocampal tissues.
Keywords：Traumatic brain injuryAstraglaus polysaccharideLearning and memoryBrain-derived neutrotrophic factor
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 419-421 )