Effect of dexmedetomidine and propofol combined with remifentanil on patients with cerebral aneurysms undergoing clipping
LIU Shu-wei
WU Jian-heng
WU Yue-hui
WANG Zhen
Abstract：Objective To explore the effect of dexmedetomidine and propofol combined with remifentanil on the patients with cerebral aneurysms undergoing clipping.Methods Sixty-six patients with cerebral aneurysms treated in our hospital from December,2014 to October,2016 were randomly divided into two groups of 33 ones each,i.e.control group,in which 33 patients received the venous injection of 0.9％ sodium chloride before the induction of anesthesia with remifentanil and propofol,and observed group,in which 33 patients received the venous infusion of dexmedetomidine before the induction of anesthesia with remifentanil and propofol.Anesthetic drug dosage and recovery time,and hemodynamics changes at the different time and the adverse reactions incidence during the surgery were observed and compared between the two groups.Results There was no significant difference in the amount of used rocuronium and remifentanil between both groups (P＞0.05).The recovery time from anesthesia was significantly longer in the observed group than that of the control group (P＜0.05).The dosage of used propofol was significandy less in the observed group than that of the control group (P＜0.05).The heart rate and mean arterious pressure were significantly lower in the observed group than those in the control group after intubation,before and after extubation (P＜0.05).The rates of occurrences of intraoperative hypertension and tachycardia,and vomiting and irritability during recovery from anesthesia were significantly lower in the observed group respectively than those in the control group (P＜0.05).Conclusion Dexmedetomide and with propofol combined with remifentanil can inhibit the cardiovascular response during tracheal intubation and extubation,decrease the dosage of propofol,increase the anesthesia effect,and make the hemodynamics more stable in the patients with cerebral aneurysms undergoing surgery.
Keywords：Cerebral aneurysmAnesthesiaDexmedetomidinePropofolRemifentanilClipping
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 400-402 )