Analysis of correlation of plasma levels of hydrogen sulfide and tumor necrosis factor-a with severity of traumatic brain injury
LIU Qing-Yun
LIU Jun
FU Jun
CHEN Yong
KUI Shi-bo
WANG Xue-Jun
Abstract：Objective To explore the correlation of plasma levels of hydrogen sulfide (H2S) and tumor necrosis factor-α(TNF-α) with severity of traumatic brain injury (TBI).Methods The plasma levels of H2S and TNF-α were determined respectively by methylene blue method and double antibody sandwich ELISA in 14 patients with mile TBI,13 patients with moderate TBI,15 patients with severe TBI and 30 healthy subjects.Results The plasma level of H2S was significantly lower in the patients with severe TBI than that in the patients with moderate TBI (P＜0.05),which was significantly lower than that in the patients with mild TBI (P＜0.05),which was significantly lower than that in the healthy subjects (P＜0.05).The plasma level of TNF-α was significantly higher in the patients with severe TBI than that in the patients with moderate TBI (P＜0.05),which was significantly higher than that in the patients with mild TBI (P＜0.05),which was significantly higher than that in the healthy subjects (P＜0.05).The plasma TNF-α levels were negatively related to the plasma H2S levels in the patients with moderate or severe TBI (P＜0.05).Conclusion It is suggested that the changes in the plasma levels of H2S and TNF-α may play an important role in the pathophysiologic process after TBI.
Keywords：Traumatic brain injuryHydrogen sulfideTumor necrosis factor-αPlasma levelCorrelation
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 398-399,402 )