Correlation between power of hippocampal electrocoagulation and pathological changes in hippocampal conduction fibers in patients with temporal lobe epilepsy
QI Xue-ling
YAO Kun
DUAN Ze-jun
ZHAI Feng
ZHOU Jian
Abstract：Objective To observe the morphological changes in the hippocampal transverse conduction fibers induced by different power coagulation lesions in the hippocampus in order to provide a reliable basis for treatment of temporal lobe epilepsy (TLE) by the electrocoagulation of hippocampus.Methods Twenty patients with TLE were treated by electrocoagulation of hippocampi with output power of 3,5 and 7 watts.The morphology of the resected hippocampi was observed under microscope after the elctrocoagulation.Results The hippocampi after the coagulation histomorphologically were mainly divided into three layers,i.e.superficial molecular layer injured by electrocoagulation,horizontal neurons layer with nuclear pyknosis in the lesion site and edema zone between the injured site and normal brain tissues.The hippocampal pyramidal cells and dentate granular cell layer structure were relatively normal.The average depth injured by 7 watts electrocoagulation power was 1.290 mm in 9 patients,by 56 mm in 7,and by 3 watts 0.335 mm in 4.The depth of thermal injury to the hippocampus increased significantly with increase in the electrocoagulation power.Conclusions The degeneration and fracture of hippocampal molecular layer of transverse fibers can be induced by the electrocoagulation.The electrocoagulation with output of 7 watts can produce the best curative effects including the prevention of the epileptic discharge level synchronization and dissemination and retaining the hippocampal memory function.
Keywords：Temporal lobe epilepsyHippocampal electro-coagulationPathological changesCurative effects
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 382-385 )