Effects of anterior temporal lobectomy on cognitive function in patients with temporal lobe epilepsy

CHEN Yan-fang; WANG Meng-yang; ZHAI Feng; LUAN Guoming; YU Si-ke; WANG Qian; ZHOU Jian

doi:10.13798/j.issn.1009-153X.2017.06.003

Abstract：Objective To investigate the effects of left or right anterior temporal lobectomy on cognitive function in patients with temporal lobe epilepsy (TLE).Methods The clinical data of 44 patients with TLE undergoing the resection of the unilateral anteriolateral temporal lobe and medial structures from 2014 to 2015 were analyzed retrospectively.The examination of Wechsler Verbal Intelligence Quotient (VIQ) and Operational Intelligence Quotient (PIQ) were performed in all the patients before and 1 year after the operation.The examinations of Wechsler Memory Quotient (MQ) including the understanding and regeneration tests were performed in all the patients 3 months and 1 year after the operation.Results The scores of PIQ were significantly higher 1 year after the operation than those before the operation in the patients with TLE undergoing left temporal lobectomy (P＜0.05).The scores of MQ were significantly higher in the patients with TLE undergoing right temporal lobectomy (P＜0.05).The scoresof understanding test were lower 3 months after the operation than those before the operation in the patients with TLE under left temporal lobectomy (P＜0.05),in whom the scores of regenerative test 3 months after the operation were insignificantly different from those before the operation (P＞0.05).The scores of regenerative test were significantly higher 1 year after the operation than those before the operation in the patients undergoing left temporal lobectomy (P＜0.05),in whom the scores of regenerative test 3 months after the operation were insignificantly different from those before the operation (P＞0.05).The scores of the understanding and regenerative tests 3 months and 1 year after the operation were insignificantly different respectively from those before the operation in the patients with TLE undergoing the right temporal lobectomy (P＞ 0.05).Conclusion The left temporal lobectomy can mainly improve PIQ,while the right temporal lobectomy can mainly improve MQ in patients with TLE.