Stereotatic EEG-guided radio-frequency thermocoagulation of epileptogenic zones in the patients with refractory epilepsy
GUAN Yu-guang
YU Si-ke
LIU Chang-qing
ZHANG Yao
CHEN Si-chang
DING Hao-ran
ZHOU Jian
LUAN Guo-Ming
Abstract：Objective To evaluate the curative effect of stereotactic electroencephalography(SEEG)-guided radio-frequency thermocoagulation (RF-THC) of the epileptogenic zone on refractory epilepsy.Methods The clinical data of 33 patients (19 male,14 female;age,4～34 years) with refractory epilepsy undergoing SEEG-guided RF-THC of the epileptogenic zones were analyzed retrospectively.SEEG were performed in order to indentify the epileptogenic zones in the patients with refractory epilepsy in whom the epileptogenic zones were not identified by video-EEG,MRI,magnetoencephalography and PET.The electrode contacts which obviously discharged (interictal frequent spikes,plus spike and ictal low-voltage fast activity) during SEEG monitoring were chosen for RF-THC lesions in all the patients.Results According to SEEG recordings,ictal discharge originated from single electrode in 5 cases,focal areas in 15 cases and more than two brain areas in 6 cases,and interictal and ictal discharge were diffused in 7 cases.No serious side effects during the RF-THC procedures were observed in all the patients.The following up from 6 to 15 months showed that there was no seizure again in 4 cases (focal epileptogenic zone) and no change in 8 cases,and seizure decreased by more than 80％ in 3 cases,by 50％～79％ in 10 cases,by 10％-49％ in 8 cases compared with the preoperation status.Conclusions SEEG-guided RF-THC is a safe and effective method to treat the refractory epilepsy.
Keywords：Refractory epilepsyStereotactic electroencephalographyEpileptogenic zoneRadio-frequency themocoagulation
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 369-371 )