Short-term curative effect and factors related to prognosis of three dimensional conformal radiotherapy combined with temozolomide chemotherapy on residual malignant gliomas after surgery
LI Jian-ming
Abstract：Objective To investigate the short-term curative effect of three dimensional conformal radiotherapy (3D-CRT) combined with temozolomide chemotherapy on the residual malignant gliomas after surgery and the factors related to the prognosis.Methods Fifty-eight patients with residues of malignant gliomas after the surgery were divided into the observed group,in which 29 patients were treated by 3D-CRT combined with temozolomide chemotherapy and the control group,in which 29 patients were treated only by 3D-CRT from November,2012 to April,2015 in Zigong Municipal Third People's Hospital.All the patients were followed up 1 year after the treatment lasting from 4 to 6 cycles.The curative effects and factors related to the prognoses were analyzed in both the groups.Results The total effective rate (68.97％,20/29) and disease control rate (86.21％,25/29) were significantly higher in the observed group than those [41.38％ (12/29) and 62.07％ (18/29),respectively] in the control group (P＜0.05).The survival rate (72.41％,21/29) was significantly higher in the observed group than that (44.83％,13/29) in the control group 1 year after the treatment(P＜0.05).The factors related to prognosis included age over 60 years,who pathological grade,preoperative Karnofsky performance score (KPS) and the completion of chemotherapy cycle in the patients with residual malignant gliomas after the surgery (P＜0.05).Conclusions The prognoses can be significantly improved by 3D-CRT combined with temozolomide chemotherapy in the patients with residual malignant gliomas after the surgery,in whom the age over 60 years,pathological grade,preoperative KPS,completion of the chemotherapy cycle were factors affecting the prognosis of patients.
Keywords：Malignant gliomasResiduesPrognosisThree dimensional conformal radiotherapyTemozolomideChemotherapy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 316-317,321 )