Relationship between neurological behavior score and plasma level of neuropeptide Y in neonates with hypoxic ischemic encephalopathy

LI Yan; LEI Xun-Ming; LI Xia

doi:10.13798/j.issn.1009-153X.2017.04.007

Abstract：Objective To investigate the relationship between the neurological behavior score and the plasma level of neuropeptide Y in the neonates with hypoxic ischemic encephalopathy (HIE).Methods The neurological behavior scores and plasma levels of neuropeptide Y were determined respectively by the neonatal behavioral neurological assessment (NBNA) and radioimmunoassay in 62 neonates with HIE (observed group) and 62 healthy neonates (control group).The outcomes were compared between both the groups.The relationship of NBNA scores with plasma levels of neuropeptide Y was analyzed by Pearson related model.Results NBNA scores [(34.01±0.64) points] were significantly lower in the observed group before the treatment than those [(38.92±0.71)points] in the control group (P＜0.05).The plasma level of neuropeptide Y [(192.74±13.620)ng/L] was significantly higher in the observed group before the treatment than that [(65.75 ± 10.00)ng/L] in the control group (P＜0.05).The NBNA scores [(37.43±0.82) points] were significantly higher after the treatment than those before the treatment in the observed group (P＜0.05).The plasma level of neuropeptide Y [(74.45 ±9.82)ng/L] was significantly lower after the treatment than that before the treatment in the observed group (P＜0.05).The neonatal Pearson model analysis showed that NBNA score was negatively related to the plasma level of neuropeptide Y in the observed group (r=-0.527,P＜0.05).Conclusions The neurological behavior score and the plasma level of neuropeptide Y are significantly abnormal in the neonates with HIE compared to those in the healthy newborns.There is significant negative correlation between NBNA score and plasma level of neuropeptide Y.