Curative effect of edaravone combined with clopidogrel on ischemic stroke and its safety in the elderly patients

WANG Xiao-ling; NI Zhi-fu; WANG Yun-fu

doi:10.13798/j.issn.1009-153X.2017.04.005

Abstract：Objective To investigate the curative effect of edaravone combined with clopidogrel on ischemic stroke and its safety in elderly patients.Methods One hundred and sixty elderly patients with ischemic stroke treated in our hospital from January,2014 to May,2016 were randomly divided into two groups,i.e.control group in which the patients (n=80) were treated by clopidogrel after the thrombolysis and observed group in which the patients were treated by edaravone combined with clopidogrel after thrombolysis.The serum levels of IL-6 and tumor necrosis factor α (TNF-α) were determined in all the patients before and 2 weeks after the treatment.The prognoses and safety were compared between both the groups.Results The effective rate (93.8％) was significantly higher in the observed group than that (75.0％) in the control group (P＜0.05).The serum levels of IL-6 and TNF-cα were significantly lower after the treatment than those before the treatment in the two groups (P＜0.05),and the serum levels of IL-6 and TNF-α in the observed group were significantly lower than those in the control group after the treatment (P＜0.05).The life quality scores were significantly higher after the treatment than those before the treatment in the observed and the control groups (P＜0.05).The life quality scores were significantly higher in the observed group than those in the control group after the treatment (P＜0.05).The incidence of symptomatic cerebral hemorrhage and non symptomatic cerebral hemorrhage were significantly lower in the observed group than those in the control group after the treatment (P＜0.05).Conclusions That the curative effect and life quality can be improved and the complications can be decreased by the application of edaravone combined with clopidogrel in the elderly patients with ischemic stroke may be related to the inhibition of serum inflammatory factors expressions including IL-6 and TNF-α.