Expression of MGMT in malignant glioma tissues and its clinical meaning
CHANG Bing-lin
Abstract：Objective To investigate the expression of 06-methyl guanine-DNA methyltransferase (MGMT) in malignant gliomas and its clinical meaning.Methods The MGMT protein expression was determined by immunohistochemiscal technique in 166 specimens of malignant gliomas tissues derived from 166 patients treated in our hospital from November,2012 to April,2014.The relationship between the MGMT protein expression level with patients' age and survival time was analyzed.Results The survival time [(24.15±3.27) months] was significantly longer in MGMT negative expression group than that [(17.35±3.16) months] in MGMT positive expression group (P＜0.01),which was significantly longer than that [(13.25± 1.34) months] in MGMT strongly positive expression group (P＜0.01).Conclusions The expression level of MGMT in the malignant gliomas tissues is correlated with the patients' prognoses.High expression level of MGMT in the malignant gliomas tissues suggests bad prognosis in the patients with malignant gliomas.
Keywords：Malignant gliomasMGMTExpression levelPrognosisRelationship
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 171-173 )