Correlativity between Ki-67 expression and peritumorous brain edema in intracranial meningiomas
ZHANG Lin
HE Yu-chao
YING Guo-long
XIE Bao-shu
YAO Wen-yi
GAO Wei-zhen
JIA Feng
YIN Yu-hua
Abstract：Objective To analyze the correlativity between the level of Ki-67 expression and peritumorous brain edema (PTBE) in the patients with intracranial meningiomas.Methods The expression of Ki-67 was detected by immunohistochemical staining in 159 specimens of the intracranial meningiomas confirmed by histopathological examination from January,2013 to January,2016.The degree of PTBE was evaluated by preoperative MRI in all the patients with intracranial meningiomas serving as the above-mentioned specimens.The correlativity between the level of Ki-67 expression in the timorous tissues and PTBE was analyzed by statistical method.Results There was significant difference in the level of Ki-67 expression among the meningiomas tissues with different degrees of PTBE (P＜0.05).The levels of Ki-67 expression were positively correlated with the degree of PTBE (rs=0.486;P＜0.01).Conclusion It is suggested that the degree of PTBE evaluated by preoperative MRI may be used to predict the expression of Ki-67 and the grade of malignancy of meningiomas,thus providing a significant basis for proper therapy and prognositic prediction.
Keywords：Intracranial meningiomasKi-67ExpressionPeritumorous brain edemaCorrelativity
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 168-170 )