Effect of lumbar cistern drainage on CSF levels of NO and ET-1 in patients with traumatic subarachnoid hemorrhage
ZENG Jia-liang
XIE Fei
YE Yong-qiang
CHEN Zhi-yuan
HAO Jian-qiang
LIU Huan
Abstract：Objective To study the effect of lumbar cistern drainage on cerebrospinal fluid (CSF) levels of nitric oxide (NO),endothelin-1 (ET-1) levels of in patients with traumatic subarachnoid hemorrhage (SAH).Methods Sixty patients with traumatic SAH treated from March,2015 to March,2016 were divided into two groups of 30 patients each,i.e.control group in which the patients received conservative treatment and observed group in which the patients received lumbar cistern drainage on the basis of conservative treatment.The NO and ET-1 concentrations in CSF,incidence of cerebral vasospasm and incidence of complications were compared between both the groups after the treatment.Results CSF level of NO [(59.2±7.0) mmol/L] was significantly higher and CSF level of ET-1 [(39.4±6.0) pg/ml] was significantly lower in the observed group than those [(51.4±4.3) mmol/L and (46.4±5.3) pg/ml respectively] in the control group after the treatment (P＜0.05).The incidences of cerebral vasospasm and complications (46.7％ and 33.3％ respectively) were significantly higher in the control group than those (16.7％ and 10.0％ respectively) in the observed group (P＜0.05).Conclusion Lumbar cistern drainage for treating traumatic SAH is safe.It can effectively increase NO content in CSF,reduce ET-1 content in CSF and decrease risk of cerebral vasospasm in the patients with traumatic SAH.
Keywords：Brain injurySubarachnoid hemorrhageLumbar cistern drainageCerebrospinal fluidNitric oxideEndothelin-1
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 162-164 )