Changes in serum levels of thyroid hormones and copeptin in patients with severe traumatic brain injury
Liu Qin-yun
LIU Jun
ZHONG Qun-qiong
YU Sheng
WEI Shi-Bo
Abstract：Objective To observe the changes in serum levels of thyroid hormones and copeptin and their effect on the prognoses in the patients with severe traumatic brain injury (TBI).Method The serum levels of thyroid hormones including thyroid-stimnlating hormone (TSH),free triiodothyronine (FT3) and free tetraidothyronina (FT4) and copeptin were determined by chemiluminescence method and ELISA respectively,in 56 patients with severe TBI treated in our hospital from March,2015 to June,2016 and 30 healthful subjects serving as control group.Result The serum levels of TSH,FT3 and FT4 were significantly lower,and the serum level of copeptin was significantly higher in the patients with severe TBI than those in the control group 24 hours after TBI (P＜0.05).The serum levels of TSH,FT3 and FT4 were significantly higher,and the serum level of copeptin was significantly lower in 18 patients with GCS score of 6～8 points than those in 38 patients with GCS score of 3～5 points 24 hours after TBI (P＜0.05).Conclusion It is suggested that in the patients with severe TBI the hypothalamic pituitary-thyroid axis is hypofunctional and the hypothalamic pituitary arginine vasopressin (AVP) system is hyperfunctional.Maybe the hyperfunctional hypothalamic pituitary AVP system is the important reason for the poor prognoses in the patients with severe TBI.
Keywords：Severe traumatic brain injuryThyroid hormoneCopeptinSerum levelsPrognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 155-157 )