Effects of different feeding methods on gut microbiota in patients with severe traumatic brain injury
RONG Liang
ZHU Xiao-mei
SHEN Song-bo
HU Wei
Abstract：Objective To compare the characteristics of gut microbiota between the patients with severe traumatic brain injury (sTBI) receiving small intestinal feeling and ones receiving gastric feeding.Methods One hundred and twenty-six patients with sTBI were divided into two groups,i.e.group A in which 66 patients received gastric feeding and group B in which 60 received small intestinal feeding.The distribution and diversity of gut microbiota were detected by Illumina sequencing in both the groups.The factors related to the bacterial flora were analyzed in the patients with nosocomial infection.Results The total bacterial species number and Bifidobacterium abundance were significantly more in group B than that in group A (P＜0.05).However,Enterococcus and Clostridium abundances were significantly higher in group A than that in group B (P＜0.05).Logistic regression analysis showed that a more complex diversity of gut microbiota was the risk factor of the nosocomial pneumonia.The increases in the total bacterial species number and Bifidobacterium abundance were the important factors to inhibit the nosocomial gastrointestinal tract infection (P＜0.05) in the patients with STBI.Conclusions The increases in the total bacterial species number and Bifidobacterium abundance can be produced by small intestinal feeding in the patients with sTBI.Under the circumstance of not increasing the microbiota diversity,the increases in total bacterial species number and Bifidobacterium abundance were the protective factors for nosocomial gastrointestinal tract infections in the patients with STBI.
Keywords：Severe traumatic brain injuryFeeding methodGut microbiotaNosocomial infection
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 152-154,157 )