Factors related to prognosis of seizure following reoperation for recurrent low grade gliomas
ZHOU Xing-wang
DONG Hui
ZHOU Qiao
JIANG Tao
LIU Yan-hui
MAO Qing
Abstract：Objective To explore the factors relate to the prognosis seizure after reoperation for low grade gliomas diagnosed as at first. Methods The clinical data of 81 epileptic patients with low grade gliomas, who underwent surgery again for the recurrent gliomas from April, 2012 to April, 2015, were analyzed retrospectively. Results Of 81 patients with seizure before the second operation, 43 still had low grade gliomas and 38 progressively had high grade gliomas according to pathological diagnosis after the second operation. Of 55 patients in whom the seizures were completely controlled (Engel class Ⅰ) 12 months after the second surgery, 29 were ones with low grade gliomas and 26 were ones with high grade gliomas. The other patients still experienced seizures differently in degree (Engel classesⅡ~Ⅳ). The logistic regression analysis suggested that the risk factors related to seizure after the reoperation included incomplete resection of the tumors, high expression of Ki-67 and age less than 38 years (P<0.05) in the patients with low grade gliomas after the reoperation, and the risk factors related to seizure was incomplete resection of the tumors in the patients with high grade gliomas after the reoperation (P<0.05). Conclusion The present results suggested that gross total resection of the tumors, age over 38 years and low expression of Ki-67 were favorable factors related to predicting complete control of seizure in recurrent low grade glioma patients, but only the gross total resection of the tumors contributed to the complete control of seizure in the patients who experienced malignant transformation.
Keywords：Recurrent low grade gliomaRisk factorsSeizureMalignant transformationKi-67
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 513-516 )