Effects of body temperature on serum levels of ischemia-modified albumin and malondialdehyde after surgery for intracranial hematomas in patients with severe traumatic brain injury
LIU Jun
YUAN Hui-chun
XU Li-xin
Abstract：Objective To investigate the effect of body temperature on the serum levels of ischemia-modified albumin (IMA) and malondialdehyde (MDA) after the surgery for the intracranial hematomas in patients with severe traumatic brain injury (sTBI). Methods Forty-five patients with sTBI after the surgery for intracranial hematomas were divided into observed group (n=25) and control group (n=20). In observed group, mild hypothermia therapy apparatus and hibernation drugs were used to control rectal temperature at 36.0~36.4℃for 7 days. In control group, conventional cooling methods were used to control rectal temperature at 36.5~37.7℃. The serum levels of IMA and MDA were detected by ELISA. Results The intracranial pressure, which began to decline 3 days after the body temperature control, was significantly lower in observed group than control group 7 days after the body temperature control (P<0.05). The prognosis was significantly better in observed group than control group 3 months after the body temperature control (P<0.05). There was no significant difference in the complications between the two groups. The serum levels of IMA and MDA were significantly lower in observed group than control group 1, 3, 5, 7 days after the body temperature control (P<0.05). Conclusions The rectal temperature which was controlled at the range from 36.0 to 36.4 has neuroprotection in the patients with sTBI after the removal of the intracranial hematomas probably due to the decrease in the serum levels of IMA and MDA.
Keywords：Severe traumatic brain injurySerum levelsIschemia-modified albuminMalondialdehydeTemperature control
Publication Date：2016-01-01
Pages：4( 412-415 )