Analysis of risk factors related to prognoses in patients with primary glioblastomas
LIU Qi
XIONG Li
TIAN Shao-bin
CHEN Jin-song
Abstract：Objective To propose a prognostic evaluation scale for the patients with primary glioblastomas based on the risk factors related to the prognosis in order to provide theoretical reference for the individual treatment of patients with primary glioblatomas. Methods All the tumor samples and clinical data of 69 patients with primary glioblastomas treated in the First People’s Hospital of Tianmen City from 1994 to 2014 were collected in this study. Cox regression analysis was used to identify the risk factors related to prognoses in the patients with primary glioblactomas. Based on these risk factors, a prognostic evaluation scale was proposed. Results The univariate analysis showed that age ≥50 years, residual tumor after the surgery, 1p/19q maintenance and wild-type IDH1 which was not mutated were risk factors related to the prognoses in the patients with primary glioblactomas (P<0.05). The prognostic evaluation scale was proposed for the patients with primary glioblastomas on the basis of the above-mentioned risk factors related to the prognosis. Multivariate analysis revealed that age≥50 years and 1p/19q maintenance were independent risk factors related to the prognoses in the patients with primary glioblactomas (P<0.05). The prognostic evaluation scale could divided the patients with primary glioblastomas into 3 levels with remarkably different survival time (P<0.01). Conclusions The more the risk factors is, the higher the prognostic evaluation scale score is and poorer the prognosis is. This prognostic evaluation scale may provide the reference for the individual treatment of Chinese patients with primary glioblastomas.
Keywords：Primary glioblastomaRisk factorPrognosisPrognostic evaluation scale
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 341-343,349 )