Analysis of prognoses in patients with recurrent multiple glioblastomas
XIE Bao-shu
ZHANG Lin
WANG Yu
JIA Feng
YIN Yu-hua
Abstract：Objective To explore the factors related to the prognoses in patients with recurrent multiple glioblastomas. Methods Of 106 patients with recurrent multiple glioblastomas, who underwent surgical resection of the tumors from January, 2005 to December, 2012 in our hospital, and were followed up, 78 suffered from solitary lesion and 28 from multiple lesions. Each patient with multiple tumors was matched with a patient with a solitary glioblastoma on the basis of age, gender, tumorous location, extent of resection, postoperative radiotherapy or chemiotherapy and Karnofsky Performance Scale (KPS) score and then case-control study was performed. The patients’survival time was analyzed by Kaplan-Meier cure and log-rank tests. Results Long-rank test showed that median overall survival time (8.5 months) was significant longer in the patients with solitary glioblastoma than that (4.5 months) in the patients with multiple glioblastomas (P<0.05). The median overall survival time (7.9 months) was significantly longer in the patients with multiple glioblastomas which were totally resected than that (3.6 months) in the patients with multiple glioblastomas which were partially resected (P<0.05). Conclusions It is suggested the prognosis in the patient with multiple glioblastomas is significantly worse than that in patient with solitary glioblastoma. And the more tumor is resected, the better the prognosis will be in the patients with multiple glioblastomas, in who the tumor should be resected totally as possible on the basis of protecting important cerebral function.
Keywords：Multiple glioblastomaSurgical resectionSurvival time
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 333-335 )