Relationship of levels of glutamate and aspartate in peritumorous tissues with seizures in patients with gliomas
YUN De-bo
YANG Yu-Jiao
ZHANG Kui
FAN Run-jin
ZHANG Yuan
DU Yi-qing
Abstract：Objective To study the relationship of the levels of glutamate and aspartate in the peritumorous tissues with seizures in order to provide the basis for understanding of pathophysiological mechanism of the epilepsy secondary to glioma. Methods Of 47 specimens of gliomas, 28 were derived from the gliomas patients with secondary epilepsy and 19 from the gliomas patients without secondary epilepsy. The levels of glutamate and aspartate in the peritumorous tissues were determined by automatic high-speed L-8900 amino acid analyzer. Results The levels of glutamate and aspartate in the peritumorous tissues were significantly higher in the gliomas patients with secondary epilepsy than those in the gliomas patients without secondary epilepsy (P<0.05). The seizure with the levels of glutamate and aspartate in the peritumorous tissues is positively correlated in the patients with gliomas. Conclusion It is suggested that the higher concentrations of glutamate and aspartate in the peritumorous tissues may be one of the pathophysiological mechanisms of seizures in the gliomas patients with secondary epilepsy.
Keywords：GliomaSecondary epilepsyGlutamateAspartatePeritumorous tissuesRelationship
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 331-332,335 )