Relationship between human plasma CXCL16 level and stenoses of intracranial and extracranial arteries

XIANG Fei; XIANG Chun-hui; WANG Kui; ZHOU Han

doi:10.13798/j.issn.1009-153X.2015.07.011

Abstract：Objective To investigate the relationship between human plasma CXC chemokine ligand 16 (CXCL16) and stenoses of intracranial and extracranial arteries. Methods The plasama levels of CXCL16 were determined by enzyme-linked immunosorbent assay (ELISA) in 54 patients with stenoses of intracranial arteries, 18 with stenoses of extracranial arteries, 28 with stenoses of intra- and eatracranial arteries and 15 healthful subjects. The relationships of the plasma levels of CXCL16 with the stenoses of the above-mentioned arteries were analyzed. Results The plasma levels of CXCLl6 [(3.25 ± 0.24) ng/ml] were significantly higher in the patients with cerebrovasclar stenoses than that [(1.15±0.17) ng/ml] in the healthful subjects (P<0.05). The plasma levels of CXCL16 were significantly higher in the patients with stenoses of intracranial arteries, ones with stenoses of extracranial arteries and ones with stenoses of intra-and extracranial arteries respedively than that in the healthful subjects (P<0.05). There were insignificantly differences in the plasma levels of CXCLl6 among the patients with stenoses of different cerebral arteries (P>0.05). The plasma levels of CXCLl6 [(3.36 ± 0.12) ng/ml] was significantly higher in the patients with severe stenoses of the cerebral arteries than that [(3.17 ± 0.07) ng/ml] in the piatients with medial stenoses of cerebral arteries (P<0.05), which was significantly higher than that [(3.02±0.11) ng]in the patients with mild stenoses of cerebral arteries (P<0.05). Conclusion It is suggested that the plasma level of CXXL16 is helpful to the prediction of severity of cerebral artery stenosis.